7-Amino-3- (2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazi

Details 7-Amino-3- (2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazi 7-Amino-3- (2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazi

1978-02-13

1979-04-24

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544238, 544 27, C07D50136

Patent

active

041513525

ABSTRACT:
Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on- 6-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. A preferred embodiment was 7-[o-(methylaminomethyl)phenylacetamido]-3-(2-carboxyalkyl-2,3-dihydro-s-t riazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.

REFERENCES:
patent: 3946000 (1976-03-01), Naito et al.
patent: 3985728 (1976-10-01), Naito et al.
patent: 3989694 (1976-11-01), Berges

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