Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-01-28
1999-11-16
Dees, Jose' G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
552528, 552529, 552536, 552538, 552510, 552623, 552625, 552626, 552629, 552630, 552642, 552646, 552647, 552648, 552650, C07D31500, C07J 3100, C07J 1300, C07J 5300, C07J 100
Patent
active
059861150
ABSTRACT:
This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids.
The new compounds represent compounds with very strong antiestrogenic action.
The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.
REFERENCES:
French, Andrew N., et al. "A synthesis of 7 .alpha.-substituted estradiols . . . ," Apr. 1993, MA, US, pp. 157-169 (XP-002051815).
"Synthesis of estradiol haptens." May 26, 1986, Columbus, OH (XP-002051816). (chemical abstract).
International Search Report.
Bittler Dieter
Bohlmann Rolf
Hegele-Hartung Christa
Heindl Josef
Heinrich Nikolaus
Dees Jos,e G.
Pryor Alton
Schering AG
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