7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their produ

Details 7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their produ 7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their produ

1997-08-20

1999-02-02

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514170, 514172, 514176, 552529, 552528, 552538, 552536, 552539, 552548, 552553, 552558, 552610, 552618, 552626, 540 47, 540113, A61K 3156, A61K 3158, A61K 4500, C07J 100

Patent

active

058665609

ABSTRACT:
This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids.
The new compounds represent compounds with very strong antiestrogenic action.
The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.

REFERENCES:
French, Andrew N., et al. "A synthesis of 7 .alpha.-substituted estradiols . . . ," Apr. 1993, MA, US, pp. 157-169 (XP-002051815).
"Synthesis of estradiol haptens." May 26, 1986, Columbus, OH (XP-002051816). (chemical abstract).
International Search Report.

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