7-(.alpha.-Sulfoacylamido)cephalosporins

Details 7-(.alpha.-Sulfoacylamido)cephalosporins 7-(.alpha.-Sulfoacylamido)cephalosporins

1976-09-02

1977-12-27

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 24, C07D50144, C07D50146, A61K 31545

Patent

active

040656195

ABSTRACT:
Novel cephalosporins of the formula, ##STR1## wherein R is a hydrogen atom or an alkyl, aryl or thienyl group, and R' is a group which constitutes together with the adjacent nitrogen atom a 5- or 6-membered ring containing 1 or 2 nitrogen atoms, which are effective particularly against Pseudomonas aeruginosa as well as against other Gram negative and positive microorganisms, for example, N-[7-(.alpha.-sulfophenylacetamido)ceph-3-em-3-ylmethyl] pyridinium 4-carboxylate, N-[7-(.alpha.-sulfo-3'-thienylacetamido)ceph-3-em-3-ylmethyl] pyridinium-4-carboxylate, and their pharmaceutically acceptable salts thereof. Sodium salt of the former is prepared by, e.g. reacting sodium 7-(.alpha.-sulfophenylacetamido) cephalosporanate with pyridine in water.

REFERENCES:
patent: 3338897 (1967-08-01), Takano et al.
patent: 3382238 (1968-05-01), Dolfini
patent: 3988327 (1976-10-01), Ishiguro et al.

Affiliated with

Also associated with

Rating

7-(.alpha.-Sulfoacylamido)cephalosporins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 7-(.alpha.-Sulfoacylamido)cephalosporins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-(.alpha.-Sulfoacylamido)cephalosporins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1039997