7-(.alpha.-SULFOACYLAMIDO) CEPHALOSPORANIC ACIDS

Details 7-(.alpha.-SULFOACYLAMIDO) CEPHALOSPORANIC ACIDS 7-(.alpha.-SULFOACYLAMIDO) CEPHALOSPORANIC ACIDS

1976-08-04

1977-06-14

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D50150, C07D50154

Patent

active

040296563

ABSTRACT:
Novel cephalosporanic acid derivatives which are active against both Gram positive and Gram negative pathogenic bacteria, particularly Pseudomonas, and which have .alpha.-sulfoacylamino group at 7-position. A few examples of the compounds are 7-(.alpha.-sulfophenylacetamido)-cephalosporanic acid, 7-(.alpha.-sulfopropionamido)-cephalosporanic acid, 7-(.alpha.-sulfocapronamido)-cephalosporanic acid. They are prepared by condensing 7-aminocephalosporanic acid or salts thereof with .alpha.-sulfocarboxylic acid or functional derivatives thereof in the presence of a solvent at -2.degree. - 10.degree. C.

REFERENCES:
patent: 3338897 (1967-08-01), Takano et al.
patent: 3382238 (1968-05-01), Dolfini et al.
patent: 3575969 (1971-04-01), Morin et al.
patent: 3579506 (1971-05-01), Lemieux et al.
patent: 3651050 (1972-03-01), Nakanishi
patent: 3660379 (1972-05-01), Morimoto et al.
patent: 3669980 (1972-06-01), Bogash et al.
patent: 3988327 (1976-10-01), Ishiguro et al.

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