7-.alpha. substituted imino 7-.beta. substituted thio cephalospo

Details 7-.alpha. substituted imino 7-.beta. substituted thio cephalospo 7-.alpha. substituted imino 7-.beta. substituted thio cephalospo

1976-03-18

1978-01-31

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D50118

Patent

active

040716821

ABSTRACT:
An improved, versatile method for producing 7-cephalosporin derivatives having a 7-alkylthio or 7-arylthio group which comprises treating a 7-substituted imino halide, imino ether or iminothio ether of 7-aminocephalosporanic acid, 7-amino-3-desacetoxycephalosporanic acid and the like with a thiolating agent in the presence of a base, to obtain the thio derivative. These products are particularly useful for conversion to 7.alpha.-alkylthio or 7.alpha.-arylthio-7-acylamino intermediates which are converted to lower alkoxy cephalosporin derivatives useful as antibacterial agents.

REFERENCES:
patent: 3840533 (1974-10-01), Dolfini et al.
patent: 3875146 (1975-04-01), Christensen et al.
patent: 3947413 (1976-03-01), Christensen et al.
patent: 3954731 (1976-05-01), Spitzer
patent: 3954744 (1976-05-01), Dolfini et al.
March, Advanced Organic Chemistry, p. 301, 1968.

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