7.alpha.-Substituted 3-oxo-17.alpha.-pregn-4-ene-21,17-carbolact

Details 7.alpha.-Substituted 3-oxo-17.alpha.-pregn-4-ene-21,17-carbolact 7.alpha.-Substituted 3-oxo-17.alpha.-pregn-4-ene-21,17-carbolact

1984-08-17

1985-12-17

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

26023957, A61K 3158

Patent

active

045593310

ABSTRACT:
Novel 7.alpha.-substituted 3-oxo-17.alpha.-pregn-4-ene-21,17-carbolactones of the formula ##STR1## wherein ##STR2## is a CC single or CC double bond or the group ##STR3## R.sup.7 is the group SR', R' being a hydrogen atom or a straight-chain or branched alkyl residue of 1-6 carbon atoms optionally substituted by a hydroxy or acyloxy group, the group COOR" or the group COR" wherein R" is an alkyl group of 1-4 carbon atoms and ##STR4## is a CC single bond or the group ##STR5## have antialdosterone activity with reduced endocrinological side effects.

REFERENCES:
patent: 4129564 (1978-12-01), Wiechert et al.
patent: 4291029 (1981-09-01), Wiechert et al.
patent: 4450107 (1984-05-01), Nickisch et al.
patent: 4450170 (1984-05-01), Beeley et al.
patent: 4500522 (1985-02-01), Nickisch et al.

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