7.alpha.-Methoxy-7.beta.-(1,3-dithietane-2-carboxamido)cephalosp

Details 7.alpha.-Methoxy-7.beta.-(1,3-dithietane-2-carboxamido)cephalosp 7.alpha.-Methoxy-7.beta.-(1,3-dithietane-2-carboxamido)cephalosp

1978-06-07

1981-04-21

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 27, C07D50118

Patent

active

042634326

ABSTRACT:
The invention relates to novel 7.alpha.-methoxycephalosporin derivatives having at the 7.beta.-position an amido group acylated by a 1,3-dithietane carboxylic acid residue and to 7.beta.-isothiazolylthioacetamido-7.alpha.-methoxycephalosporins having antibacterial activity by themselves and, as the case may be, capable of being converted into the aforesaid 7.alpha.-methoxycaphalosporin derivatives. The compounds of this invention exhibit excellent antibacterial activity and are particularly effective against gram negative bacteria.

REFERENCES:
patent: 3516997 (1970-06-01), Takano et al.
patent: 4007176 (1977-02-01), Berger et al.
patent: 4008246 (1977-02-01), Ochiai et al.
patent: 4017488 (1977-04-01), Hiraoka et al.
patent: 4034090 (1971-07-01), Berger et al.
patent: 4058609 (1977-11-01), Demarinis et al.

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