Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-03-28
1976-12-21
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
260243C, 260468J, A61K 31545, C07D50122, C07D50132, C07D50134, C07D50142
Patent
active
039989500
ABSTRACT:
Derivatives of 7-aminocephalosporanic acid of the formula: ##STR1## wherein the carbon atom marked with an asterisk represents an asymmetry center of the molecule, A represents an aromatic nucleus, preferably phenyl which may be substituted by alkyl having 1-4 carbon atoms, halogen, hydroxy or alkoxy having 1-4 carbon atoms, or a heterocyclic nucleus, preferably 2- or 3-thiophene which may be, for example, substituted by halogen, R represents a hydrogen atom or a straight or branched chain lower alkyl radical, R.sub.1 represents a hydrogen atom, a hydroxy group, an acetoxy or pyridinium group. The invention includes the compounds as such or in the form of separated epimers as well as the corresponding pharmaceutically acceptable salts with alkali or alkaline-earth metals, with suitable organic bases or corresponding suitable organic or inorganic acid addition salts. Also method of preparing same. The compounds have powerful antibacterial action against gram-positive and gram-negative bacteria.
REFERENCES:
patent: 3489752 (1970-01-01), Crast
patent: 3518260 (1970-06-01), Spencer et al.
Takano, "Chemical Abstracts," 1972, vol. 76, p. 420, abstract 153,762u.
Broggi Renato
Libassi Giuseppe
Pifferi Giorgio
ISF S.p.A.
Rizzo Nicholas S.
Wheeler David E.
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