7.alpha.-Halogeno-3-oxo-1,4-pregnadiene-21,17.beta.-carbolactone

Details 7.alpha.-Halogeno-3-oxo-1,4-pregnadiene-21,17.beta.-carbolactone 7.alpha.-Halogeno-3-oxo-1,4-pregnadiene-21,17.beta.-carbolactone

1976-12-22

1978-03-14

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955R, 2603973, 2603974, C07J 2100, C07J 100

Patent

active

040790541

ABSTRACT:
Described are 3-oxo-7.alpha.-halogeno-17.alpha.-1,4-pregnadiene-21,17.beta.-carbolactone s and compounds related thereto, i.e. 2',3'.alpha.-tetrahydrofuran-2'-spiro-17(7.alpha.-halogeno-1,4-androstadie ne-3-ones) and (17R)-spiro-[7.alpha.-halogeno-1,4-androstadiene-17,1'-cyclobutane]-3,2'-d iones, all of which are valuable as aldosterone antagonists. Also described are the corresponding 7.beta.-hydroxy derivatives useful as intermediates.

REFERENCES:
patent: 3509136 (1970-04-01), Brown
patent: 3845041 (1974-10-01), Chinn

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