7-[.alpha.-(GUANYL-1-UREIDO)PHENYLACETAMIDO]-3-SUBSTITUTED CEPHA

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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424246, C07D50136

Patent

active

040395359

ABSTRACT:
7-[.alpha.-(guanyl-1-ureido)phenylacetamido]-3-(1-methyl-1H-tetrazol-5-ylth iomethyl)-3-cephem-4-carboxylic acid, 7-[.alpha.-(3-guanyl-1-ureido)phenylacetamido]-3-(5-methyl-1,3,4-thiadiazo l-2-ylthiomethyl)-3-cephem-4-carboxylic acid and related compounds, the pharmaceutically acceptable non-toxic salts and certain esters thereof are valuable broad spectrum antibiotics demonstrating high levels of activity against Pseudomonas species.

REFERENCES:
patent: 3579514 (1971-05-01), McGregor
patent: 3734907 (1973-05-01), Crast
patent: 3757015 (1973-09-01), Crast
patent: 3766175 (1973-10-01), Zemieux et al.
patent: 3767655 (1973-10-01), Cheney et al.
patent: 3769277 (1973-10-01), Long et al.
patent: 3796709 (1974-03-01), Breuer et al.
patent: 3905966 (1975-09-01), Kukolja et al.

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