7-Alpha-(2-aminothiazole)-acetamido-cephalosporins

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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424246, C07D50160

Patent

active

040804984

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula --NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula --SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

REFERENCES:
patent: 3218318 (1965-11-01), Flynn
patent: 3516997 (1970-06-01), Takano et al.
patent: 3872115 (1975-03-01), Sugimoto et al.
patent: 3890309 (1975-06-01), Ochiai et al.

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