7-alkylidene cephalosporanic acid derivatives and methods of usi

Details 7-alkylidene cephalosporanic acid derivatives and methods of usi 7-alkylidene cephalosporanic acid derivatives and methods of usi

1994-12-09

1997-05-13

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514201, 514204, 514205, 514207, 514208, 514209, 540221, 540222, 540226, 540227, 540228, 540229, 540230, C07D50122, C07D50158, A61K 31545

Patent

active

056293062

ABSTRACT:
Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of .beta.-lactamase enzymes.

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patent: 5348952 (1994-09-01), Bissolino et al.
patent: 5356888 (1994-10-01), Alpegiani
patent: 5364848 (1994-11-01), Doherty et al.
patent: 5446037 (1995-08-01), Maiti et al.
Srinivasan Chandrasekaran, et al; "Synthesis of Substituted .beta.-Lactams by Addition of Nitromethane to 6-Oxopenicillanates and 7-Oxocephalosporanates", J. Org. Chem., vol. 42, No. 24; pp. 3972-3974; 1977.
Shoichiro Uyeo, et al; "Synthesis of (6R, 7R)-Phenylacetylmethyl-3(1-Methyl-1H-Tetrazol-5-YL)Thiomethyl-1-Oxa-1-Deth iacephalosporanic Acid"; Heterocycles, vol. 13; pp. 255-257; 1979.
H. E. Applegate, et al; "7-[2-Hydroxyethyl]Cephalosporanic Acid Derivatives"; Tetrahedron Letters; No. 19; pp. 1637-1640; 1979.

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