Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-12
2005-07-12
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S202000, C514S203000, C514S204000, C514S206000, C514S208000, C540S215000, C540S222000, C540S224000, C540S225000, C540S226000, C540S227000, C540S229000
Reexamination Certificate
active
06916801
ABSTRACT:
The invention provides compounds of formula (I):wherein: R1-R4and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula (I), wherein R1and R2are each independently hydrogen, (C1-C10)alkyl, (C2-C10)alkenyl, (C2-C10)alkenyl, (C3-C8)cycloalkyl, (C1-C10)alkoxy, (C1-C10)alkanoyl, (C1-C10)alkanoyloxy, (C1-C10)alkoxycarbonyl, aryl, heterocycle, halo, cyano, nitro, —COORe, —C(═O)NRfRg, —OC(═O)NRfRg, NRfRg, or —S(O)nRh; R3is hydrogen, halo, aryl, heteroaryl, —S(O)nRh, or —CH═CHC(═O)NRmRp; R4is hydrogen; A is thio, sulfinyl, or sulfonyl; and intermediates useful for the synthesis of compounds of formula (I).
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Chen, Y. L., et al.,
Buynak John D.
Vogeti Lakshminarayana
Alamx, LLC
Berch Mark L.
Schwegman Lundberg Woessner & Kluth P.A.
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