7-Alkyl and cycloalkyl-substituted imidazotriazinones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S184000

Reexamination Certificate

active

06943163

ABSTRACT:
The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.

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Beavo, J.A., and Reifsnyder, D.H., “Primary Sequence of Cyclic Nucleotide Phosphodiesterase Isozymes and the Design of Selective Inhibitors,” TIPS, 11: 150-155 (1990).
Stoclet, J.-.C., Keravis, R., Komas, N., and Lugnier, C., “Cyclic Nucleotide Phosphodiesterase as Therapeutic Targets in Cardiovascular Diseases,” Exp. Opin. Invest. Drugs, 4(11): 1081-1100 (1995).

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