7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-

Details 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1- 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-

1985-08-02

1987-06-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544316, 544362, 546183, C07D47104

Patent

active

046737375

ABSTRACT:
7.beta.-Acylamino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxyli c acid antibiotic compounds, esters and salts thereof, and the corresponding 7-amino and protected 7-amino 1-carbacephalosporins are provided. The 3-trifluoromethylsulfonyloxy-substituted 1-carbacephalosporins also are useful in a process for preparing 3-halo-1-carbacephalosporins which comprises reacting a 3-triflate ester with a lithium halide in an aprotic polar solvent.

REFERENCES:
patent: 4226866 (1980-10-01), Christensen et al.
patent: 4275207 (1981-06-01), Ratcliffe et al.
Evans et al, Tetrahedron Letters, vol. 26 (32), 3783-3790.
Evans, Chem. Abst., 104-5677b.
Hatanaka et al, Tetrahedron Letters, vol. 24 (44), 4837-4838.
Hirata et al, Chem. Abst. 93-239247t.
Application for Continuation Grant No. GM33328, Davis A. Evans, Harvard University, Feb. 16, 1984.
Application for Continuation Grant No. GM33328, Davis A. Evans, Harvard University, Mar. 13, 1985.

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