7,8-Didehydro-2-decarboxy-2-hydroxymethyl-PGI.sub.1 compounds

Details 7,8-Didehydro-2-decarboxy-2-hydroxymethyl-PGI.sub.1 compounds 7,8-Didehydro-2-decarboxy-2-hydroxymethyl-PGI.sub.1 compounds

1978-07-03

1979-06-05

Trousof, Natalie

Harness for working animal

542429, 26034622, C07D30793

Patent

active

041574419

ABSTRACT:
The present invention relates to novel 7,8-didehydro-2-decarboxy-2-hydroxymethyl-PGI.sub.1 compounds, which are intermediates for preparing the corresponding 7,8-didehydro-PGI.sub.1 compounds. The novel prostacyclin-type end products are endoperoxide cyclooxygenase inhibitors which prevent the conversion of unsaturated fatty acids to endoperoxides (e.g., PGG.sub.2 and PGH.sub.2). By virtue of this pharmacological property these analogs represent potent antiinflammatory agents.

REFERENCES:
johnson et al., Prostaglandins 12 (6) pp. 915-929 (Dec. 1976).

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