7,8-Cyclopentano[H]-1,2,3,4-tetrahydroisoquinoline-1'-ones

Details 7,8-Cyclopentano[H]-1,2,3,4-tetrahydroisoquinoline-1'-ones 7,8-Cyclopentano[H]-1,2,3,4-tetrahydroisoquinoline-1'-ones

1974-03-28

1976-08-31

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260287D, 260289D, 260286R, 424258, C07D21704

Patent

active

039780678

ABSTRACT:
Provided are 5-alkoxy-2-alkyl-7,8-cyclopentano[ h]-1,2,3,4-tetrahydroisoquinoline-1'-ones of the formula ##SPC1##
Wherein R and R.sub.1 are the same or different lower alkyl groups, acid addition salts and quaternary ammonium salts thereof, and pharmaceutical compositions containing one or more of the compounds useful as hypotensive agents, and processes of producing the compounds.
Also provided are novel 5-alkoxy-2-alkyl-1,2,3,4-tetrahydroisoquinoline intermediates of the formula ##SPC2##
Wherein A is CHO-, HOOC-CH=CH-, or HOOC-CH.sub.2 -CH.sub.2 -, R and R.sub.1 are the same or different lower alkyl groups, and acid addition salts and quaternary ammonium salts thereof.

REFERENCES:
koo, J. Am. Chem. Soc., vol. 75, 1891ff (1953).
Burger, "Medicinal Chemistry" pp. 42, 497.

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