7, 8 and 9-substituted tetracycline compounds

Details 7, 8 and 9-substituted tetracycline compounds 7, 8 and 9-substituted tetracycline compounds

2006-08-22

2006-08-22

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S496000

Reexamination Certificate

active

07094806

ABSTRACT:
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.

REFERENCES:
patent: 2980584 (1961-04-01), Hammer
patent: 2990331 (1961-06-01), Neumann et al.
patent: 3007965 (1961-11-01), Growich
patent: 3062717 (1962-11-01), Hammer
patent: 3165531 (1965-01-01), Blackwood et al.
patent: 3226436 (1965-12-01), Petlsl et al.
patent: RE26253 (1967-08-01), Petlsl et al.
patent: 3338983 (1967-08-01), Patiai et al.
patent: RE26271 (1967-09-01), Boothe et al.
patent: 3341585 (1967-09-01), Bitha et al.
patent: 3345379 (1967-10-01), Martell
patent: 3345410 (1967-10-01), Winterbottom
patent: 3360561 (1967-12-01), Zambrano
patent: 3373193 (1968-03-01), Sohroeder et al.
patent: 3397230 (1968-08-01), Winterbottom et al.
patent: 3403179 (1968-09-01), Zambrano
patent: 3454697 (1969-07-01), Joyner et al.
patent: 3483251 (1969-12-01), Zambrano
patent: 3518308 (1970-06-01), Martell, Jr.
patent: 3557280 (1971-01-01), Weber et al.
patent: 3579578 (1971-05-01), Hlavka et al.
patent: 3674859 (1972-07-01), Beutel et al.
patent: 3849493 (1974-11-01), Conover
patent: 3862225 (1975-01-01), Conover
patent: 3901942 (1975-08-01), Bernardi et al.
patent: 3957980 (1976-05-01), Noseworthy
patent: 4018889 (1977-04-01), Armstrong
patent: 4024272 (1977-05-01), Rogalski et al.
patent: 4126680 (1978-11-01), Armstrong
patent: 5248797 (1993-09-01), Sum
patent: 5281628 (1994-01-01), Hlavka et al.
patent: 5284963 (1994-02-01), Sum et al.
patent: 5326759 (1994-07-01), Hlavka et al.
patent: 5328902 (1994-07-01), Sum et al.
patent: 5371076 (1994-12-01), Lee et al.
patent: 5380888 (1995-01-01), Sum et al.
patent: 5386041 (1995-01-01), Sum et al.
patent: 5401729 (1995-03-01), Sum et al.
patent: 5401863 (1995-03-01), Hlavka et al.
patent: 5420272 (1995-05-01), Sum et al.
patent: 5430162 (1995-07-01), Sum et al.
patent: 5442059 (1995-08-01), Sum et al.
patent: 5457096 (1995-10-01), Sum et al.
patent: 5466684 (1995-11-01), Sum et al.
patent: 5494903 (1996-02-01), Hlavka et al.
patent: 5495018 (1996-02-01), Sum et al.
patent: 5495030 (1996-02-01), Sum et al.
patent: 5495031 (1996-02-01), Sum et al.
patent: 5512553 (1996-04-01), Sum et al.
patent: 5529990 (1996-06-01), Hlavka et al.
patent: 5530117 (1996-06-01), Hlavka et al.
patent: 5532227 (1996-07-01), Golub et al.
patent: 5567692 (1996-10-01), Sum et al.
patent: 5639742 (1997-06-01), Lee et al.
patent: 5675030 (1997-10-01), Krishnan et al.
patent: 5789395 (1998-08-01), Amin et al.
patent: 5834450 (1998-11-01), Su
patent: 5886175 (1999-03-01), Sum et al.
patent: 6617318 (2003-09-01), Nelson et al.
patent: 6683068 (2004-01-01), Nelson et al.
patent: 6818634 (2004-11-01), Nelson et al.
patent: 6818635 (2004-11-01), Nelson et al.
patent: 6841546 (2005-01-01), Draper et al.
patent: 6846939 (2005-01-01), Nelson et al.
patent: 2004/0242548 (2004-12-01), Draper et al.
patent: 0535346 (1993-04-01), None
patent: 0536515 (1993-04-01), None
patent: 0582788 (1994-02-01), None
patent: 0582790 (1994-02-01), None
patent: 0582810 (1994-02-01), None
patent: 0582829 (1994-02-01), None
patent: 0616190 (1994-10-01), None
patent: 951252 (1964-03-01), None
patent: 1469384 (1977-04-01), None
patent: WO-96/34852 (1996-11-01), None
patent: WO-99/37306 (1999-07-01), None
Alves, A.B., et al., “Short synthesis of azafluorenone alkaloids using transition metal-catalyzed cross coupling tactics,”Tetrahedron Lett., vol. 29(18):2135-36 (1988).
Berge, S.M., et al., “Pharmaceutical Salts,”J. Pharm. Sci., vol. 66(1):1-19 (1977).
Cheng, W., et al., “Synthetic connections to the aromatic directed metalation reaction. Iterative ortho metalation-cross coupling tactics for the construction of polypherryls,”Tetrahedron Lett., vol. 28(43):5097-98 (1987).
Muller, D., et al., “A new strategy for teh synthesis of biflavonoids via arylboronic acids,”Tetrahedron Lett., vol. 32(20):2229-32 (1991).
Murahashi, S-I, et al., “Sterreoselective synthesis of alkenes and alkenyl sulfides from alkenyl halides using palladlum and ruthenium catalyst,”J. Org. Chem., vol. 44(14):2408 (1979).
Sharp, M.J., et al., “Synthetic connections to the aromatic directed metalation reaction, Functionalized aryl boronic acids by Ipso borodesilylation. General syntheses of unsymmetrical biphenyls and m-terphenyls,”Tetrahedron Lett., vol. 28(43)5093-96 (1987).
Silverman, “The Organic Chemistry of Drug Design and Drug Action,”Academic Press, Chp. 8, pp. 352-400 (1992).
Tamao, K. et al., “Nickel-phosphine complex-catalyzed Grignard coupling. I. Cross-coupling of alkyl, aryl, and alkenyl Grignard reagents with aryl and alkenyl halides: general scope and limitations,”Bull. Chem. Soc. Jpn., vol. 49(7):1958-69 (1976).
Van den Bogart, et al., “Doxycycline in combination chemotherapty of a rat leukemia,”Cancer Res., vol. 8686-8690 (1988).
Koza, D.J., “The synthesis of 8-substituted tetracycline derivatives, the first 8-position carbon-carbon bond,”Tetrahedron Lett., vol. 41:5017-20 (2000).
Koza, D.J., “Synthesis of 7-substituted tetracycline derivatives,”Organic Lett., vol. 2:815-17 (2000).
Barden, T.C., “Glycylcyclines' .3.9-Aminodoxycyclinecarboxamides,”J. Med. Chem., vol. 37:3205-11 (1994).
Sum, P., “Glycylcyclines.1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines,”J. Med. Chem., vol. 37(1):184-8 (1994).
Boothe, J., et al., “6-Deoxytetracyclines.I. Chemical Modification by Electrophilic Substitution,”J. Am. Chem. Soc., vol. 82:1253-4 (1960).
Martell, et al., “6-deoxytetracyclines. VII. Alkylated aminotetracyclines possessing unique antibacterial activity,”J. Med. Chem., vol. 10(3):359-63 (1967).
Sum, P.E., et al., “Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-938,”Bioorg. Med. Chem. Lett., vol. 9(10):1459-62 (1999).

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