Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-07-11
1981-06-09
Sutto, Anton H.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546 45, A61K 31485, C07D48902
Patent
active
042725410
ABSTRACT:
Disclosed are 7,8 and 7-8 substituted 4,5.alpha.-epoxymorphinan-6-one compounds characterized by the structural formula: ##STR1## In the foregoing formula R.sub.1 may be H or methyl, R.sub.2 is cyclopropylmethyl, cyclobutylmethyl, allyl or tetrahydrofurfuryl, R.sub.3 is H, .beta.-methyl, .beta.-ethyl or .alpha.-ethyl and R.sub.4 is H or .alpha.-methyl. Particular compounds corresponding to the foregoing description are useful as mixed analgesics
arcotic antagonists whereas others have been found to be pure narcotic antagonists.
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von Braun, et al., Chemische Berichte, vol. 59, pp. 1081-1090 (1926).
Kotick Michael P.
Leland David L.
Polazzi Joseph O.
Schut Robert N.
Jeffers Jerome L.
Miles Laboratories Inc.
Rivers Diana G.
Sutto Anton H.
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