7-[3-Substituted isoxazol-5-yl]-acetamido-cephalosporanic acids

Details 7-[3-Substituted isoxazol-5-yl]-acetamido-cephalosporanic acids 7-[3-Substituted isoxazol-5-yl]-acetamido-cephalosporanic acids

1974-12-17

1977-03-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260243C, 2602391, 424271, C07D50120, A61K 31545

Patent

active

040102645

ABSTRACT:
Novel heterocyclic amides of the formula ##STR1## wherein R is selected from the group consisting of lower alkyl and aryl optionally substituted with at least one member of the group consisting of chlorine, fluorine, nitro, amino and lower alkyl and a tertiary alkyl group, R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, carboxyl, lower alkoxycarbonyl, an alkali metal, alkaline earth metal or amine salt of carboxyl, a carbamyl, cyano, an amino and chlorine, R.sub.2 is selected from the group consisting of hydrogen, halogen, cyano, an amino, lower aralkoxycarbonylamino, lower alkyl, carboxyl esterified with lower alkyl, aryl or aralkyl and carbamoyl optionally substituted on the nitrogen atom with lower alkyl or a phenyl and Q is selected from the group consisting of ##STR2## X is selected from the group consisting of hydrogen, hydroxy and lower alkanoyloxy and U is selected from the group consisting of amido forming groups or a group OY, wherein Y is selected from the group consising of hydrogen, salt forming groups, and ester forming groups, or COOY and CH.sub.2 X together form a lactone or lactam, having antibacterial properties, their preparation and novel intermediates thereof.

REFERENCES:
patent: 3516997 (1970-06-01), Takano et al.
Hackh's Chemical Dictionary (Fourth Ed.), p. 248, (1969).

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