7[2(Substituted phenyl)2-(amino)acetamido]cephalosporin derivati

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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544 19, 544 26, 544 30, 2602391, 424271, A61K 31545, C07D50122, C07D50132

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active

041623142

ABSTRACT:
Novel .beta.-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R.sup.1 is hydrogen, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-yl, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiadiazol-5-yl; and n is an integer from 0 to 8; or a readily-cleavable ester or physiologically-acceptable salt thereof.

REFERENCES:
patent: 3985741 (1976-10-01), Crast, Jr. et al.
patent: 4012382 (1977-03-01), Bouzard et al.

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