7-[2-[(Substituted benzoyl)amino]acetamido]cephalosporins

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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544 22, 544 23, 544 24, 544 25, 544 29, C07D50159

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active

043384366

ABSTRACT:
Cephalosporin antibiotics of the formula ##STR1## wherein R is cyclohexadienyl, phenyl or substituted phenyl, 2-thienyl, 3-thienyl, 2-furyl or 3-furyl; R.sub.1 is a substituted phenyl having 1 to 4 hydroxy substituents or 1 to 3 amino substituents; and wherein Q is halo methoxy, methyl or a group of the formula --CH.sub.2 R.sub.2 wherein R.sub.2 is alkanoyloxy, carbamoyloxy, alkoxy, halo, pyridinium or substituted pyridinium or a group of the formula --SR.sub.3 wherein R.sub.3 is alkyl, phenyl, substituted phenyl or a 5 or 6 membered-heteroaryl group having from 1 to 4 heteroatoms selected from the group consisting of O, S, and N; are highly active broad spectrum antibiotics especially useful in the treatment of infections attributable to the gram-negative microorganisms.

REFERENCES:
patent: 3917588 (1975-11-01), Chauvette
patent: 3982011 (1976-09-01), Schmidt et al.
patent: 4064343 (1975-12-01), Chauvette
patent: 4087424 (1978-05-01), Saikawa et al.
Japanese Published Application No. 121,292/75 (abstract).
German Offenlegungschrift No. 2,520,561 (abstract) Kocsis et al.
Japanese Published Application No. 48,686/76 (abstract) Iwanami et al.
Japanese Published Application No. 11,724/76 (abstract) Yamanouchi Pharm.

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