7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline comp

Details 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline comp 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline comp

1988-02-26

1990-10-09

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514309, 546123, 546156, A61K 3140, A61K 31495, C07D40114

Patent

active

049621122

ABSTRACT:
Naphthyridine and quinoline compounds having the formula: ##STR1## wherein A is CH or N; Z is an amine having the formula: ##STR2## R is o,p-difluorophenyl or p-fluorophenyl; and R.sub.1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

REFERENCES:
patent: 4616019 (1986-10-01), Chu, I
patent: 4730000 (1988-03-01), Chu, I

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