7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and pro

Details 7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and pro 7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and pro

1978-03-09

1980-05-06

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 8, 544 21, 544 27, 544 28, 548194, C07D50146, C07D50122, C07D50136, A61K 31545

Patent

active

042017793

ABSTRACT:
Cephem derivatives of the formula ##STR1## in which R.sup.1 denotes hydrogen or low-molecular alkoxy, R.sup.2 denotes hydrogen, optionally substituted alkyl, phthalide or a cation, X denotes sulfur, oxygen or CH.sub.2 and A denotes hydrogen, alkoxy, halogen or a group --CH.sub.2 Y, in which Y represents hydrogen, acyloxy, alkoxy, optionally substituted carbamoyloxy or a group --SR.sup.3, in which R.sup.3 can represent acyl, alkyl or an optionally substituted 5-membered or 6-membered heterocyclic structure are disclosed as valuable antibiotics which are well suited for combating Gram-positive and in particular Gram-negative infections and also have an unexpectedly good action against penicillinase-forming staphylococci.

REFERENCES:
patent: 4008246 (1977-02-01), Ochiai et al.
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4132789 (1979-02-01), Nomura et al.

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