7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephal

Details 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephal 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephal

1979-08-08

1981-07-14

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, 544 25, 544 27, 544 28, A61K 31545, C07D50146

Patent

active

042786711

ABSTRACT:
A 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido] cephalosporin derivative of the formula; ##STR1## wherein R.sub.3 is hydrogen or a residue of a nucleophilic compound; R.sub.2 NH is an amino group which may optionally be protected, pharmaceutically acceptable salt or ester thereof, is found to have excellent anti-bacterial activity against a broad spectrum of bacteria inclusive of gram-negative bacteria such as Escherichia coli, Serratia marcescens, Proteus rettgeri, Enterobacter cloacae and Citrobacter freundii. Thus, this compound may be used for an antibacterial agent in therapeutical purposes.

REFERENCES:
patent: 4033950 (1977-07-01), Cook et al.
patent: 4066762 (1978-01-01), Dunn et al.
patent: 4098888 (1978-07-01), Ochiai
patent: 4202893 (1980-05-01), Heymes et al.

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