7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-al kyl-5

Details 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-al kyl-5 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-al kyl-5

1986-02-19

1987-10-06

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540227, A61K 31545, C07D50136

Patent

active

046983384

ABSTRACT:
O-Substituted oximinocephalosporins represented by the formula ##STR1## wherein R is a 5-membered or 6-membered heterocycle, preferably amino-substituted, e.g., 2-aminothiazol-4-yl, R.sub.1 is an arylalkyl, aryloxyalkyl, or arylthioalkyl group, especially substituted benzyl; R.sub.2 is a 1,2,4-triazin-3-yl thio group; and M is a salt or a biologically labile ester group; are potent antibacterial agents. Also provided are antibiotic formulations of said compounds and a method for treating infectious diseases in man or animals comprising the administration of said compounds.

REFERENCES:
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4200745 (1980-04-01), Katner
patent: 4279793 (1981-07-01), Durckheimer et al.
patent: 4288436 (1981-09-01), Takaya et al.
patent: 4304770 (1981-12-01), Takaya et al.
patent: 4327210 (1982-04-01), Montavon et al.
patent: 4425340 (1984-01-01), Teraji et al.
patent: 4477448 (1984-10-01), Hamberger et al.

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