Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-04-12
1980-12-02
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 21, 544 22, 544 23, 544 25, 544 27, 544 28, A61K 31545, C07D50134
Patent
active
042371287
ABSTRACT:
Compounds of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 and R.sub.3 are independently selected from methyl, ethyl, i-propyl, and n-propyl; R.sub.4 is hydrogen, sodium, potassium or certain ester groups, and X is hydrogen, ##STR2## R.sub.6 is hydrogen or lower alkyl; R.sub.7 is hydrogen, lower alkyl, ##STR3## or --(CH.sub.2).sub.n -N-(lower alkyl).sub.2 ; R.sub.8 is hydrogen, sodium or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as antibacterial agents.
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*Elks, "Recent Advances in the Chemistry of .beta.-Lactam Antibiotics", from J. J. de Konig et al., Stereospecific Synthesis of Biologically Active Cephalosporin R-Sulfoxides, (1977), pp. 161-166.
Cimarusti Christopher M.
Koster William H.
Sykes Richard B.
Coughlan, Jr. Paul M.
Davis Stephen B.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
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