Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-07-08
1991-10-08
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514427, 548517, 548562, A01N 4336, A61K 3140, C07D40506, C07D20730
Patent
active
050554840
ABSTRACT:
7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids, 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyheptanoic acids of the formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the indicated meanings, and the corresponding .delta.-lactones of the formula II ##STR2## processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.
REFERENCES:
patent: 4647576 (1987-03-01), Hoefle
patent: 4681893 (1987-07-01), Roth
patent: 4851427 (1989-07-01), Wareing
Phosphorus and the Related Group V Elements, E. Zbiral et al., vol. 2, No. 1, pp. 29-34, Jul. 1972.
Chemical Abstracts, vol. 93, 239089t, Dec. 22, 1980, European Search Report.
Stokker et al.; "3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors, 1. Structural Modification of 5-Substituted 3,5-Dihydroxypentanoic Acids and Their Lactone Derivatives", J. Med. Chem., vol. 28, (1985), pp. 347-358.
Hoffman et al., "3-Hydroxy-3-methylglutaryl-coenzyme A Reductanse Inhibitors, 2. Structural Modification of 7-(Substituted aryl)-3,5-dihydroxy-6-heptenoic Acids and Their Lactone Derivatives", J. Med. Chem., vol. 29, No. 2, (1986) pp. 159-169.
Stokker et al.; "3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors, 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic Acids and Their Lactone Derivatives", J. Med. Chem., vol. 29, (1986), pp. 170-181.
Baader Ekkehard
Beck Gerhard
Jendralla Heiner
Kerekjarto Bela
Hoechst Aktiengesellschaft
Tsung Frederick F.
Wax Robert A.
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