7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic a

Details 7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic a 7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic a

1995-03-20

1997-03-04

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546113, A61K 3147, C07D47104

Patent

active

056079427

ABSTRACT:
7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,
X.sup.2 is hydrogen, halogen, amino or other radical,
R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical,
R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical,
R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1,
and addition products thereof.

REFERENCES:
patent: 4698350 (1987-10-01), Daum et al.
patent: 4771055 (1988-09-01), Domagala et al.
patent: 4859776 (1989-08-01), Chu et al.
patent: 4889857 (1989-12-01), Araki et al .
patent: 4990517 (1991-02-01), Petersen et al.
patent: 5043156 (1991-08-01), Matsumoto et al.
patent: 5075319 (1991-12-01), Lesher et al.
patent: 5457104 (1995-10-01), Bartel et al.
Horst Spielmann et al, Erste ergebnisse der Validierung von in vitro Phototoxizitatstests im Rahmen eines EG/COLIPA Projektes, ALTEX Jan. 1994, 22-31.
Sparfloxacin Monograph Adis, 35-39 (1994).
James H. Paton et al, Clinical Features and Management of Adverse Effects of Quinolone Antibacterials, Drug Safety, 6 1991, pp. 9-27.
John M. Domagala, Quinolone activity and side-effect relationships, Journal of Antimicrobial Chemotherapy (1994) 33, 685-706.
Emad Rizk, A worldwide clinical overview of lomefloxacin, a once-daily fluoroquinolone, International Journal of Antimicrobial Agents, 2 (1992), 67-78.
M. Amdur et al., Casarett and Doull's Toxicology: The Basic Science of Poisons 4th ed., McGraw-Hill, Inc., New York, 1993, pp. 33 and 476-477.
M. Furukawa et al., Iyakuhin Kenkyu, 21(5), pp. 989-97 (1990).
Chemical Abstracts, vol. 4, 1986, p. 521, No. 50861t, Dainippon.
Chemical Abstracts, vol. 111, 1989, p. 742, No. 97210q, Iwata.
Chemical Abstracts, vol. 111, 1989, p. 721, No. 153779w, Chiba.
Egawa et al Journal of Medicinal Chemistry, vol. 27, No. 12, Dec. 1984 pp. 1543-1549.
Liebig's Ann. der Chemie, vol. 677 (1964) p. 155, Birkofer.

Affiliated with

Also associated with

Rating

7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2146133