6H-oxazolo[4,5-e]indole derivatives as nicotinic...

Details 6H-oxazolo[4,5-e]indole derivatives as nicotinic... 6H-oxazolo[4,5-e]indole derivatives as nicotinic...

2007-11-06

2007-11-06

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S106000, C544S142000, C544S358000, C544S367000, C546S184000, C546S192000, C546S196000, C546S201000, C548S215000, C548S217000, C548S218000, C514S231500, C514S252120, C514S315000, C514S375000

Reexamination Certificate

active

10476306

ABSTRACT:
Compounds of the formula I in which R1, R2, R3and R4are as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the prophylaxis or treatment of psychoses, schizophrenia, depression, anxiety states, dementia, in particular Alzheimer's disease and Lewy bodies dementia, neurodegenerative disorders, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, Tourette's syndrome, learning and memory restrictions, bulimia anorexia nervosa or other eating disorders, compulsvie behaviour, premenstrual syndrome, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds, and for the treatment of disorders which are characterised by an excess of circulating serotonin or by serotonergic hyperactivity

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Makosza, Mieczyslaw et al: “Synthesis of 1, 3, 4, 5-tetrahydropyrrolo ′4, 3, 2-del quinoli nes via the vicarious nucleophilic substitution of hydrogen” TETRAHEDRON (1995), 51(26), 7263-76.
John E Macor et al : “1-(2-Aminomethyl) -3-methyl-8,9-dihydropyr ane ′3, 2-eindole:A Ratationalyy Restricted Phenolic Analog of the Neurotransmitter Serotonin and Agonist Selective for Serotonin (5-HT2-Type) Receptors” Journal of Medicinal Chemistry, American Chemical Society. Washington,US, vol. 35, No. 20, Oct. 2, 1992, pp. 3625-3632.

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