6H-isoxazolo(5,4-d)pyrazolo(3,4-b)pyridines, and their use as an

Details 6H-isoxazolo(5,4-d)pyrazolo(3,4-b)pyridines, and their use as an 6H-isoxazolo(5,4-d)pyrazolo(3,4-b)pyridines, and their use as an

1985-12-23

1986-11-11

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 83, 546120, 546119, A61K 31415, C07D49814

Patent

active

046223266

ABSTRACT:
There are disclosed compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl, arylloweralkyl, aryl or heteroaryl; R.sub.2 is hydrogen or loweralkyl; R.sub.3 is loweralkyl, loweralkoxyloweralkyl, cycloalkyl, arylloweralkyl or heteroarylmethyl; and R.sub.4 is hydrogen or loweralkyl; or a pharmaceutically acceptable acid addition salt thereof, which are useful for alleviating pain and lowering blood pressure, methods for synthesizing them, and pharmaceutical compositions comprising an effective amount of such a compound.

REFERENCES:
patent: 4020072 (1977-04-01), Hoehn

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