6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives usef

Details 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives usef 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives usef

1983-10-11

1985-07-16

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602393P, 2602457, 548421, 548492, A61K 3155, C07D48704

Patent

active

045297240

ABSTRACT:
Compounds of the present invention are of the formula (I): ##STR1## wherein X is oxygen or two hydrogens, R.sup.1 is a variety of substituents or hydrogen and R.sup.2 is hydrogen, alkoxy, alkyl, CF.sub.3, halogen, NO.sub.2, OH or dialkylamino. The compounds are useful as blood pressure lowering agents and may be used in the treatment of hypertension. Also, part of the invention are pharmaceutical compositions and uses and intermediates for compounds of formula (I).

REFERENCES:
Journal of Medicinal Chemistry, 1980, vol. 23, No. 4, pp. 462-465, W. B. Wright et al.
E. E. Garcia et al., Journal of Heterocyclic Chemistry, vol. 7, pp. 1161-1163, (1970).

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