6H-[1]benzopyrano[4,3-b]quinolines and their use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S062000, C546S014000

Reexamination Certificate

active

11219940

ABSTRACT:
This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I:The invention further provides compositions including the compounds, methods for the use of the compounds, and methods of preparation of the compounds.

REFERENCES:
patent: 3493579 (1970-02-01), Lyle et al.
patent: 3518258 (1970-06-01), von Strandtmann et al.
patent: 3518272 (1970-06-01), von Strandtmann et al.
patent: 3518273 (1970-06-01), von Strandtmann et al.
patent: 3541100 (1970-11-01), Ramirez et al.
patent: 3551565 (1970-12-01), Clarke et al.
patent: 3600375 (1971-08-01), Wang et al.
patent: 4418068 (1983-11-01), Jones
patent: 5318976 (1994-06-01), Luzzio et al.
patent: 5998402 (1999-12-01), Miller et al.
patent: 6110962 (2000-08-01), Wrobel et al.
patent: 2002/0140132 (2002-10-01), Guarr et al.
patent: 2002/0183310 (2002-12-01), Miller et al.
patent: 2003/0087955 (2003-05-01), Miller et al.
patent: 2003/0166643 (2003-09-01), Mcdevitt
patent: 2003/0171412 (2003-09-01), Malamas et al.
patent: 2003/0199570 (2003-10-01), Coghlan et al.
patent: 376166 (1990-07-01), None
patent: 2361642 (2001-10-01), None
patent: 2374412 (2002-10-01), None
patent: 63295579 (1988-01-01), None
patent: 63238079 (1988-04-01), None
patent: 1051092 (1982-07-01), None
patent: 264124 (1986-10-01), None
patent: WO 94/20869 (1994-09-01), None
patent: WO 95/06640 (1995-03-01), None
patent: WO 96/10015 (1996-04-01), None
patent: WO 96/19458 (1996-06-01), None
patent: WO 97/09348 (1997-03-01), None
patent: WO 98/45272 (1998-10-01), None
patent: WO 99/07847 (1999-02-01), None
patent: WO 89/02739 (1999-04-01), None
patent: WO 00/01716 (2000-01-01), None
patent: WO 00/59897 (2000-10-01), None
patent: WO 00/61230 (2000-10-01), None
patent: WO 00/62765 (2000-10-01), None
patent: WO 00/76529 (2000-12-01), None
patent: WO 01/24785 (2001-04-01), None
patent: WO 01/64665 (2001-09-01), None
patent: WO 01/72713 (2001-10-01), None
patent: WO 02/30407 (2002-04-01), None
patent: WO 02/46164 (2002-06-01), None
patent: WO 02/46168 (2002-06-01), None
patent: WO 02/051821 (2002-07-01), None
patent: WO 02/068548 (2002-09-01), None
patent: WO 03/044006 (2003-05-01), None
patent: WO 03/045930 (2003-06-01), None
patent: WO 03/050095 (2003-06-01), None
patent: WO 03/051863 (2003-06-01), None
patent: WO 03/061701 (2003-07-01), None
patent: WO 04/000817 (2003-12-01), None
patent: WO 2004/073610 (2004-09-01), None
patent: WO 2004/094400 (2004-11-01), None
patent: WO 2004/094401 (2004-11-01), None
patent: WO 2004/094451 (2004-11-01), None
patent: WO 2004/099122 (2004-11-01), None
patent: WO 2004/103973 (2004-12-01), None
patent: WO 2005/018636 (2005-03-01), None
patent: WO 2005/051972 (2005-06-01), None
patent: WO 2005/082880 (2005-09-01), None
patent: WO 2005/123757 (2005-12-01), None
Malecki, N. et al.: Synthesis of condensed quinolines and quinazolines as DNA ligands. Bioorg. & Medicnal Chem. vol. 12, pp. 641-647, Feb. 1, 2004.
Wright, G. et al.: A study of the catalytic reductive products of 2,3-dihydro-6-methoxy-3-(6-nitroveratrylidene)-4H-benzopyran-4-one. J. Heterocyc. Chem. vol. 13, pp. 1181-1185, 1976.
Al-Azzawi, “The menopause and its treatment in perspective,”Postgraduate Medical Journal(2001) 77:292-304.
Bhat et al., “A novel human estrogen receptor beta: identification and functional analysis of additional N-terminal amino acids,”Journal of Steroid Biochemistry&Molecular Biology(1998) 67(3):233-240.
Black et al., “Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice ,”Life Sciences(1980) 26(17):1453-1458.
Brincat, “Hormone replacement therapy and the skin,”Maturitas(2000) 35(2):107-117.
Calvin, “Oestrogens and wound healing,”Maturitas(2000) 34(3):195-210.
Couse et al., “Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse,”Endocrinology(1997) 138(11):4613-4621.
Cowley et al., “Estrogen receptors alpha and beta form heterodimers on DNA,”Journal of Biological Chemistry(1997) 272(32):19858-19862.
Crandall, “Estrogen replacement therapy and colon cancer: a clinical review,”Journal of Women's Health&Gender-Based Medicine(1999) 8(9):1155-1166.
Edsall et al., “ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template,”Bioorganic&Medicinal Chemistry(2003) 11(16):3457-3474.
Epperson et al., “Gonadal steroids in the treatment of mood disorders,”Psychosomatic Medicine(1999) 61(5):676-697.
Finking et al., “[The effects of estrogen in the cardiovascular system],”Zeitschrift fur Kardiologie(2000) 89(5):442-453.
Fitzpatrick et al., “Expression of estrogen receptor-beta protein in rodent ovary,”Endocrinology(1999) 140(6):2581-2591.
Goldstein et al., “A pharmacological review of selective oestrogen receptor modulators,”Human Reproduction Update(2000) 6(3):212-224.
Green et al., “Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A,”Nature(1986) 320(6058):134-139.
Hall et al., “The multifaceted mechanisms of estradiol and estrogen receptor signaling,”Journal of Biological Chemistry(2001) 276(40):36869-36872.
Henke et al., “A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta,”Journal of Medicinal Chemistry(2002) 45(25):5492-5505.
Hurn et al., “Estrogen as a neuroprotectant in stroke,”Journal of Cerebral Blood Flow&Metabolism(2000) 20(4):631-652.
Kuiper et al., “Cloning of a novel receptor expressed in rat prostate and ovary,”Proceedings of the National Academy of Sciences of the USA(1996) 93(12):5925-5930.
Kuiper et al., “Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta,”Endocrinology(1997) 138(3):863-870.
Levin, “Cell localization, physiology, and nongenomic actions of estrogen receptors,”Journal of Applied Physiology(2001) 91(4):1860-1867.
Levin, “Cellular Functions of the Plasma Membrane Estrogen Receptor,”Trends in Endocrinology&Metabolism(1999) 10(9):374-377.
McDonnell et al., “The mechanism of action of steroid hormone receptors,” Ch. 20, pp. 351-361,Principles of Molecular Regulation, Eds. Michael & Means. Totowa, NJ: Humana Press, 2000.
McDonnell, “Selective estrogen receptor modulators (SERMs): A first step in the development of perfect hormone replacement therapy regimen,”Journal of the Society of Gynecologic Investriction(2000) 7(1 Suppl):S10-S15.
McKenna et al., “Nuclear receptor coregulators: cellular and molecular biology,”Endocrine Review(1999) 20(3):321-344.
Mendelsohn et al., “The protective effects of estrogen on the cardiovascular system,”New England Journal of Medicine(1999) 340(23):1801-1811.
Meyers et al., “Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl-5,6,11, 12-tetrahydrochrysenes,”J. Med. Chem. (1999) 42(13):2456-2468.
Miller et al., “Constrained phytoestrogens and analogues as ERbeta selective ligands,”Bioorganic&Medicinal Chemistry Letters(2003) 13(14):2399-2403.
Monyer et al., “Glucose deprivation neuronal injury in cortical culture,”Brain Research(1989) 483(2):347-354.
Moggs et al., “Estrogen receptors: orchestrators of pleiotropic cellular responses,”EMBO Reports(2001) 2(9):775-781.
Monk et al., “Use of estrogens for the prevention and treatment of Alzheimer's disease,”Dementia&Geriatric Cognitive Disorders(2000) 11(1):1-10.
Paige et al., “Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta,”Proceedings of the National Academy of Sciences of the USA(1999) 96

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