(6a.alpha.,10a.alpha.,11a.alpha.)-2-(2-Pyridinyl)-1,3,4,6,6a,7,8

Details (6a.alpha.,10a.alpha.,11a.alpha.)-2-(2-Pyridinyl)-1,3,4,6,6a,7,8 (6a.alpha.,10a.alpha.,11a.alpha.)-2-(2-Pyridinyl)-1,3,4,6,6a,7,8

1981-05-26

1983-04-26

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544344, A61K 31495, C07D47104

Patent

active

043813020

ABSTRACT:
(6a.alpha.,10a.alpha.,11a.alpha.)-2-(2-pyridinyl)-1,3,4,6,6a,7,8,9,10,10a,1 1,11a-dodecahydro-2H-pyrazino[1,2-b]isoquinoline and derivatives or acid addition salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressant agents and for treating sedation caused by antihypertensive therapy.

REFERENCES:
patent: 2958694 (1960-11-01), Jannsen
patent: 3773951 (1973-11-01), Rodriguez
patent: 4078063 (1978-03-01), Lumma et al.
patent: 4081542 (1978-04-01), Lumma et al.
patent: 4082844 (1978-04-01), Lumma et al.
Thunus et al., Ann. Pharm. Fran, 32, 569-574, (1974).
Saxena et al., Indian J. Chem., 13, 230-237, (1975).

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