62112, a novel human dehydrogenase and uses thereof

Details 62112, a novel human dehydrogenase and uses thereof 62112, a novel human dehydrogenase and uses thereof

2007-01-23

2007-01-23

Yu, Misook (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C436S518000

Reexamination Certificate

active

09945326

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated DHDR-7 nucleic acid molecules, which encode novel human dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR-7 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR-7 gene has been introduced or disrupted. The invention still further provides isolated DHDR-7 polypeptides, fusion polypeptides, antigenic peptides and anti-DHDR-7 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 1074617 (2001-02-01), None
patent: WO 00/58473 (2000-10-01), None
patent: WO 01/44448 (2001-06-01), None
patent: WO 01/44448 (2001-06-01), None
patent: WO 01/55301 (2001-08-01), None
Gura (Science, 1997 , 278:1041-1042).
Jain (Sci. Am., 1994, 271:58-65).
Curti (Crit. Rev. in Oncology/Hematology, 1993, 14:29-39).
Hartwell et al (Science, 1997 , 278:1064-1068).
Wang, J. et al. 2000 J. Biol. Chem. 275 (1): 507-513.
Bowie et al (Science, 1990, 247:1306-1310).
Burgess et al (J of Cell Bio. 111:2129-2138, 1990).
Lazar et al (Molecular and Cellular Biology, 1988, 8:1247-1252).
Aoyama et al, (1994, J. Biol. Chem. vol. 269, pp. 19088-19094).
The definition of “ameliorate” in Merriam-Webster Online dictionary downloaded from url>>m-w.com.
Voet et al., (Biochemistry, John Wileys &Sons, 1990, pp. 284-289).
Voet et al (1990, Biochemistry, John Wiley & Sons, p. 507).
Scott et al (Nature Genetics, 1999, 21:440-443).
Skolnick et al. (2000, Trends in Biotech. 18:34-39).
Bork (2000, Genome Research 10:398-400).
Doerks et al. (1998, Trends in Genetics 14:248-250).
Brenner (1999, Trends in Genetics 15:132-133).
Bork et al. (1996, Trends in Genetics 12:425-427).
Bowie et al. (1990, Science 247:1306-1310).
Johnson et al. (Brit. J. Cancer 84(10):1424-1431).
Shi et al., (J. Chem. Inf. Comput. Sci. 40:367-379).
Smith et al. (1997 , Nature Biotechnology 15:1222-1223).
Aoyama, T. et al., “Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients,” Am J Hum Genet., Aug. 1995; 57(2):273-83.
EMBL Accession No. AAB94839 for human protein sequence SEQ ID N:16010. Jun. 26, 2001.
EMBL Accession No. AAH16781 for Human cDNA sequence SEQ ID N:16009. Jun. 26, 2001.
EMBL Accession No. AAS40878 for cDNA encoding novel human enzyme polypeptide #94. Dec. 17, 2001.
EMBL Accession No. AAU23008 for Novel human enzyme polypeptide #94. Dec. 17, 2001.
EMBL Accession No. AK024012 forHomo sapienscDNA FLJ13950 fis, clone Y97AA1001048, weakly similar to ACYL-COA Dehydrogenase, Very-Long-Change Precursor (EC 1.3.99.-). Sep. 28, 2000.
EMBL Accession No. BE615243 for 601281562F1 NIH—MGC—39Homo sapienscDNA clone IMAGE:3623559 5′, mRNA sequence. Aug. 25, 2000.
GenBank Accession No. P50544 for Acyl-CoA dehydrogenase, very-long-chain specific, mitochondrial precursor (VLCAD) (MVLCAD).
GenBank Accession No. T15905 for hypothetical protein E04F6.1—Caenorhabditis elegans.
GenBank Accession No. W40274 for zc80g09.r1 Pancreatic IsletHomo sapienscDNA clone Image:328672 5′similar to SW:ACDV—RAT P45953 ACYL-COA Dehydrogenase, Very-Long-Chain Specific Precursor ;, mRNA sequence.
GenBank Accession No. AF078854 forHomo sapiensNPD002 mRNA, complete cds.
GenBank Accession No. AK022568 forHomo sapienscDNA FLJ12506 fis, clone NT2RM2001700, weakly similar to ACYL-COA Dehydrogenase, Very-Long-Chain Specific (EC 1.3.99.-).
GenBank Accession No. AK024012 forHomo sapienscDNA FLJ13950 fis, clone Y79AA1001048, weakly similar to ACYL-COA Dehydrogenase, Very-Long-Chain Specific Precursor (EC 1.3.99.-).
GenBank Accession No. BC007970 forHomo sapiens, clone MGC:14452 IMAGE:4304209, mRNA, complete cds.
GenBank Accession No. BE206217 for ba93d09.×1 NIH—MGC—5Homo sapienscDNA clone Image:2924849 3′ similar to SW:ACDV—BOVIN P48818 ACYL-COA Dehydrogenase, Very-Long-Chain Specific Precursor ;, mRNA sequence.
GenBank Accession No. BAB14104 for unnamed protein product [Homo sapiens].
Cox, K.B. et al. “Chromosomal locations of the mouse fatty acid oxidation genesCpt1a, Cpt1b, Cpt2, Acadvl, and metabolically relatedCratgene”Mammalian genome9:608-610 (1998).
Strausberg, R., “Homo sapiensacyl-Coenzym A dehydrogenase family, member 9, mRNA (cDNA close MGC:14970 IMAGE: 3935925), complete cds.” NCBI [online] Bethesda, MD: National Center for Biotechnology Information [Retrieved on Nov. 8, 2005]. Retrieved from the internet: <URL: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=33989435/>. NCBI Accession No. BC013354.

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