6-thioxanthines

Details 6-thioxanthines 6-thioxanthines

1987-07-28

1990-05-15

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544273, 514262, C07D47306, A61K 3152

Patent

active

049258478

ABSTRACT:
A 6-thioxanthine of general formula I or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.3 is a C.sub.2 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group and R.sub.8 is a C.sub.1 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group provided that when R.sub.3 is an ethyl, n-propyl or n-butyl group, R.sub.8 is a C.sub.3 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group.
These 3,8-disubstituted-6-thioxanthines have enhanced bronchodilator activity.

REFERENCES:
patent: 3900474 (1979-08-01), Ginger et al.
patent: 4546182 (1989-10-01), Kjellin et al.
patent: 4710503 (1987-12-01), Hofer

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