6-sulfoxyphenol derivatives, their preparation and their use as

Details 6-sulfoxyphenol derivatives, their preparation and their use as 6-sulfoxyphenol derivatives, their preparation and their use as

1984-09-07

1987-04-28

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur containing

568 27, 568442, 548301, 549 39, C07C14900, C07C14932

Patent

active

046616365

ABSTRACT:
Compounds of the formula I ##STR1## where R.sup.1 is hydrogen, lower alkyl, lower alkoxy, amino or dialkylamino; R.sup.2 and R.sup.3 are O-alkyl, N-dialkyl or S-alkyl, or R.sup.2 and R.sup.3 together represent --X--(CH.sub.2).sub.m --X, a carbonyl group or an imino group NR, and m is 2-6; where R.sup.4 is lower alkyl, cycloalkyl, alkenyl or dialkylamino, and where R.sup.5 is lower alkyl or cycloalkyl, and where n is 1 or 2, have excellent cytoprotective effects.
They are prepared by reacting compounds II ##STR2## with formaldehyde or a reagent producing formaldehyde.

REFERENCES:
patent: 3780110 (1973-12-01), Gay
patent: 3804883 (1974-04-01), Galantay
patent: 3917704 (1975-11-01), Kaiser et al.
Chemical Abstracts Service, Registry Handbook, 1965-1971, p. 3204 R.
Journal of the Chemical Society (1978), pp. 633-638.

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