Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-11-22
1991-06-25
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 26, 536 27, 536 28, C07H 1914, C07H 19167, C07H 19173, C07H 1920
Patent
active
050268368
ABSTRACT:
6-Sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and 3 and 7 deaza and 8 aza derivatives thereof of structure: ##STR1## wherein Z is H or --NH.sub.2 ;
REFERENCES:
Fieser et al., Reagents for Organic Synthesis, vol. 2, p. 281, line 32, Wiley Interscience, New York, N.Y., 1969.
Fieser et al., Reagents for Organic Synthesis, vol. 3, Wiley-Interscience, New York, N.Y., 1972, see p. 50, line 10.
Fieser et al., Reagents for Organic Synthesis, vol. 5(a), Wiley-Interscience, New York, N.Y., 1975, p. 104, line 5.
Fieser et al., Reagents for Organic Synthesis, vol. 5(b), Wiley-Interscience, New York, N.Y., 1975, see p. 33, line 12, p. 127, line 10.
Fieser et al., Reagents for Organic Synthesis, vol. 7, Wiley-Interscience, New York, N.Y., 1983, see p. 58, line 9.
Fieser et al., Reagents for Organic Synthesis, vol. 8(a), Wiley-Interscience, New York, N.Y., 1980, see p. 2, lines 9-10.
Fieser et al., Reagents for Organic Synthesis, vol. 8(b), Wiley-Interscience, New York, N.Y., 1983, see p. 44, lines 1-2.
March, J., Advanced Organic Chemistry, Reactions, Mechanism & Structure, McGraw-Hill Book Co., New York, N.Y., 1968 see p. 887, sec. 9-28.
Paterson et al., Chemical Abstracts, vol. 88:58916m, 1978.
Paterson et al., Chemical Abstracts, vol. 88:45687n, 1978.
Synthesis and in Vivo Antitumor Activity of 2-Amino-9-H-Purine-6-Sulfenamide, -Sulfinamide, and -Sulfonamide and Related Purine Ribonucleosides, Revanker, et al., J. Medicinal Chemistry, 1990, 33, 121.
Oxidation of 2-Amino-9- -D-Ribofurnosylpurine-6-Sulfenamide to the Corresponding 6-Sulfonamide Facilitates Changes in Biologic Characterization that include Activity Against Thiopurine-Refractory Experimental Leudemia, Finch et al., Cancer Letters, 50(1990), 63-70.
Chemotherapeutic Characterization in Mice of 2-Amino-9- -D-Ribofuranosylpurine-6-Sulfinamide (Sulfinosine), A Novel Purine Nucleoside with Unique Antitumor Properties, Avery et al., Cancer Research 50, 2625, May 1, 1990.
Hanna Naeem B.
Revankar Ganapathi R.
Robins Roland K.
Boswell Herb
Brown Johnnie R.
Crane L. Eric
Nucleic Acid Research Institute
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