6-substituted-tetrahydrobenz[cd]indoles

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

548406, 548421, 548436, C07D20990, A61K 3140

Patent

active

052294099

ABSTRACT:
The present invention involves certain 4-amino-6-substituted-tetrahydrobenz[cd]indoles and their use in treating disorders which can be benefited by modifying 5-HT A receptor function.

REFERENCES:
patent: 3336307 (1967-08-01), Shen
patent: 3671541 (1972-06-01), Bormann et al.
patent: 3674801 (1972-07-01), Bormann et al.
patent: 4057560 (1977-11-01), Bormann et al.
patent: 4110339 (1978-08-01), Bach et al.
patent: 4252803 (1981-02-01), Webb
patent: 4282240 (1981-08-01), Baldwin et al.
patent: 4447438 (1984-05-01), Ledelec et al.
patent: 4576959 (1986-03-01), Flaugh
patent: 4745126 (1988-05-01), Leander
patent: 4983622 (1981-01-01), Flaugh
patent: 5021438 (1991-06-01), Junge et al.
patent: 5039820 (1991-08-01), Kress et al.
patent: 5096908 (1992-03-01), Gidda et al.
Fuller et al., Advances in Drug Research, 17, pp. 349-380 (1988).
Glennon et al., J. Med. Chem., 30, pp. 1-12 (1987).
Gonzalez-Heydrich et al., J. Clin. Psychiatry, 51, pp. 5-12 (1990).
Saxena et al., J. of Cardiovasc. Pharmacol., 15, pp. 517-534 (1990).
Dreteler et al., J. Card. Pharm., 14, 770 (1989).
Dreteler et al., J. Card. Pharm., 17, 488 (1991).
Shepheard et al., Eur. J. Pharm., 186, 267 (1990).
Lucot et al., Pharm. Biochem. & Beh., 33, 627 (1989).
Othmer et al., J. Clin. Psych., 48(5), 201 (1987).
Bowen et al., Ann. Neurol., 32, 112 (1992).
Bowen et al., The Lancet, 339, 132 (1992).
Bowen et al., Trends in Neurosciences, 15, 84 (1992).
Prehn et al., Eur. J. Pharm., 203, 213 (1991).
Dourish et al., Psychopharmacology, 86, 197 (1985).
Hutson et al., Eur. J. Pharm., 129, 347 (1986).
Dourish et al., Psychopharmacology, 94, 58 (1988).
Dourish et al., Brain 5-HT.sub.1A Receptors: Behavioral and Neurochemical Pharmacology, Chapter 18, Ellis Harwood, publisher.
Dourish et al., Brain Res. Bull., 15, 377 (1985).
Montgomery et al., Psychopharmacology, 94, 110 (1988).
Hutson et al., Eur. J. Pharm., 150, 361 (1988).
Dourish et al., Appetite, 7, Suppl., 127 (1986).
Gilbert et al., Psychopharmacology, 93, 349 (1987).
Dourish et al., Psychopharmacology, 95, 185 (1988).
Neill et al., Eur. J. Pharm., 151, 329 (1988).
Dourish et al., Brain 5-HT.sub.1A Receptors: Behavioral and Neurochemical Pharmacology, Chapter 20, Ellis Harwood, publisher (1987).
Hilleman et al., Arch. Intern. Med., 152, 350 (1992).
McBride et al., Pharm. Bio. and Beh., 34, 381 (1989).
Flaugh et al., J. Med. Chem., 31, 1746-1753 (1988).
Kruse et al., J. Org. Chem., 49, 4761-4768 (1984).
Bach et al., J. Med. Chem., 23, 481-491 (1980).
Derwent Abstract 57337, For FR 2,471,373.
Haefliger et al., Tet. Lett., 25(3), 289 (1984).
Somei et al., Chemical Abstracts, 107, 39610b for JP62-63,567.
T. W. Greene, Protective Groups in Organic Synthesis, Chapter 7, John Wiley and Sons, New York (1973).
J. W. Barton, Protective Groups in Organic Synthesis, Chapter 2, McOmie, ed., Plenum Press, New York, (1973).
The Vocabulary of Organic Chemistry, Orchin et al., John Wiley and Sons., Inc., publishers, p. 126.
A. Schoenberg et al., J. Org. Chem., 39, 3327 (1974).
A. Schoenberg et al., J. Org. Chem., 39, 3318 (1974).
Raucher et al., Tet. Lett., 21, 4061 (1980).
Nichols et al., Org. Prep. & Proc. Ind., 9, 277 (1977).
Leanna et al., Tet. Lett., 30, 3935 (1989).
O. Mitsunobu, Synthesis, Jan. 1981, p. 1.
J. P. Freemer et al., Synthesis, Dec. 1974, p. 894.
Sugi et al., Bull. Chem. Soc. Jap., 43, p. 1489 (1970).
Morrison & Boyd, Chapter 22, Organic Chemistry, 3rd Ed. (1973).
Wong et al., J. Neural Transm., 71, 207-218 (1988).
Wong et al., J. Neural Transm., 64, 251-269 (1985).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

6-substituted-tetrahydrobenz[cd]indoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-substituted-tetrahydrobenz[cd]indoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-substituted-tetrahydrobenz[cd]indoles will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1760933

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.