6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hyd

Details 6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hyd 6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hyd

1987-12-10

1989-09-19

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544296, 544333, A61K 31505

Patent

active

048681857

ABSTRACT:
Certain trans-6-[[(substituted)pyrimidin-5-yl]ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

REFERENCES:
patent: 4613610 (1986-09-01), Wareing
patent: 4647576 (1987-03-01), Hoefle et al.
patent: 4668794 (1987-05-01), Wareing
patent: 4681893 (1987-07-01), Roth

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