6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents

Details 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents

1992-02-07

1993-06-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, 424451, 424456, 424464, 424489, A61K 31505, C07D47104

Patent

active

052235033

ABSTRACT:
2-amino-4-hydroxypyrido[2,3-d]pyrimidines, having a 6-substituted ethyl or ethenyl group, are useful antineoplastic agents.

REFERENCES:
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patent: 4684653 (1987-08-01), Taylor et al.
patent: 4902796 (1990-02-01), Taylor et al.
Hurlbert, et al., J. Med. Chem., 11:711-717 (1968).
Gossett, et al., The Fourth Chemical Congress of North America Book of Abstracts (Am. Chem. Soc.), MEDI-0022 (1991).

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