6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-h

Details 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-h 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-h

1989-10-06

1991-03-05

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514275, 514332, 514333, 514334, 514336, 514344, 514345, 514349, 514352, 546256, 546257, 546258, 546284, 546286, 546287, 546289, 546296, 546297, 546301, 546302, 546303, 546304, 546307, 546311, 546341, 544296, 544333, C07D40506, A61K 31365

Patent

active

049978373

ABSTRACT:
Certain trans-6-[[(substituted)pyridin-3-yl]-alkyl- and alkenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

REFERENCES:
patent: 4613610 (1986-09-01), Wareing
patent: 4647576 (1987-03-01), Hoefle et al.
patent: 4681893 (1987-07-01), Roth
patent: 4735958 (1988-04-01), Roth et al.

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