6-substituted pyrazolo[3,4-d]pyrimidin-4-ones and compositions a

Details 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones and compositions a 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones and compositions a

1997-03-26

1999-11-02

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544262, A61K 31505, C07D48704

Patent

active

059771186

ABSTRACT:
6-Substituted pyrazolo[3,4-d]pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or hypertension.

REFERENCES:
patent: 3211731 (1965-10-01), Schmidt et al.
patent: 3716555 (1973-02-01), Howarth et al.
patent: 3821282 (1974-06-01), Hoyle et al.
Silver et al. "Cyclic GMP Potentiation by WIN 58237, a Novel Cyclic Nucleotide . . . " J. Pharm. Exp. Ther. 271, 1143-1148 (1994).

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