6-Substituted purine 3',5'-cyclic nucleotides

Details 6-Substituted purine 3',5'-cyclic nucleotides 6-Substituted purine 3',5'-cyclic nucleotides

1973-06-08

1976-04-06

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424180, C07H 1920

Patent

active

039488861

ABSTRACT:
Described herein are novel 6-alkylthio and 6-arylalkylthio purine 3',5' cyclic nucleotides variously exhibiting adenyl cyclase and (in animal studies) tumor inhibitory properties, interferon potentiation, antiviral activity, and the ability to activate adenosine 3',5'-cyclic phosphate-dependent protein kinase while enjoying resistance to phosphodiesterase hydrolysis superior to that of its naturally occuring analog. The compounds are obtained by alkylation of the corresponding 6-thio nucleotide, which is in turn provided by a novel synthetic route.

REFERENCES:
patent: 2993039 (1961-07-01), Schroeder
patent: 3300479 (1967-01-01), Hanze
patent: 3535207 (1970-10-01), Shiro et al.
patent: 3712885 (1973-01-01), Weimann et al.

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