6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds

Details 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds

1982-12-28

1985-06-04

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544238, 544239, 514247, C07D23704, A61K 3150

Patent

active

045214158

ABSTRACT:
6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds possessing strong platelet aggregation inhibiting activity and blood pressure depressing activity, having the general formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen, lower alkyl, lower alkylthio or the grouping R.sup.5 --NH-- where R.sup.5 is lower alkyl; R.sup.3 is phenyl, pyridyl, benzyl, lower alkyl or a substituted phenyl group carrying at any desired position on the benzene ring thereof the grouping: ##STR2## where R.sup.1 has the same meaning as given above; R.sup.4 is hydrogen or halogen; n is 0 or 1; and when both R.sup.2 and R.sup.3 are lower alkyl groups, R.sup.2 and R.sup.3 may be combined together with the bridging member ##STR3## where m is 2 or 3, as well as physiologically acceptable acid-addition salts thereof, and processes for preparing them.

REFERENCES:
patent: 3975388 (1976-08-01), Hakim et al.
R. T. Morrison and R. N. Boyd, "Organic Chemistry", 3rd Ed., pp. 727-752, Chapters 22 and 23.

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