6-substituted penem esters as anti-inflammatory and anti-degener

Details 6-substituted penem esters as anti-inflammatory and anti-degener 6-substituted penem esters as anti-inflammatory and anti-degener

1990-04-05

1992-02-18

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514192, 540310, C07D49900, A61K 31425

Patent

active

050894897

ABSTRACT:
6-substituted penem esters of formula (I): ##STR1## wherein R.sub.1 is halogen or a C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, phenyl, phenoxy, benzyl or sulphonyloxy group; R.sub.2 is a C.sub.1 -C.sub.4 alkyl, benzyl diphenylmethyl ##STR2## group where A is C.sub.1 -C.sub.4 alkyl, benzyl, p-nitrobenzyl or p-methoxybenzyl; and R.sub.3 is an organic radical, are elastase inhibitors and thereby useful antiinflammatory and antidegenerative agents.

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Enzyme Kinetics, Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems, Irwin H. Segel, Wiley-Interscience Publication, John Wiley & Sons, New York, pp. 100-103, 110-111.

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