6-substituted penem esters as anti-inflammatory and anti-degener

Details 6-substituted penem esters as anti-inflammatory and anti-degener 6-substituted penem esters as anti-inflammatory and anti-degener

1988-06-14

1990-09-04

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514192, 540310, C07D49900, A61K 31425

Patent

active

049544934

ABSTRACT:
6-substituted penem esters of formula (I): ##STR1## wherein R.sub.1 is halogen or a C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, phenyl, phenoxy, benzyl, or sulphonyloxy group; R.sub.2 is a C.sub.1 -C.sub.4 alkyl, benzyl diphenylmethyl ##STR2## group where A is C.sub.1 -C.sub.4 is C.sub.1 -C.sub.4 alkyl, benzyl, p-nitrobenzyl or p-methoxybenzyl; and R.sub.3 is an organic radical, are elastase inhibitors and thereby useful antiinflammatory and antidegenerative agents.

REFERENCES:
patent: 4482565 (1984-11-01), Foglio et al.
patent: 4711886 (1987-12-01), Finke et al.
patent: 4797396 (1989-01-01), Finke et al.
patent: 4847247 (1989-07-01), Thompson et al.
Heterocycles, vol. 16., No. 11, 1981, pp. 1919-1921.
Gazz. Chim. Ital., vol. 111 (9-10), 1981, pp. 371-377.
Enzyme Kinetics, Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems, Irwin H. Segel, Wiley-Interscience Publication, John Wiley & Sons, New York, pp. 100-103, 110-111.

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