Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1980-11-18
1987-09-08
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540310, 514192, C07D49900, A61K 3143
Patent
active
046924426
ABSTRACT:
The invention relates to 2-penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.a represents an organic radical bonded by a carbon atom to the ring carbon atom, a free, etherified or esterified hydroxy or mercapto group or a halogen atom, R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom, or an etherified mercapto group, and R.sub.2 represents a hydroxy group or an R.sub.2.sup.A radical that together with the carbonyl grouping --C(.dbd.O)-- forms a protected carboxyl group, and to salts of such compounds with salt-forming groups, processes for the manufacture of such compounds, pharmaceutical preparations containing compounds of the formula I with pharmacological properties, and their use. The compounds have antibiotic activity.
REFERENCES:
patent: 4168314 (1979-09-01), Christensen et al.
patent: 4260618 (1981-04-01), Christensen et al.
patent: 4331676 (1982-05-01), Gosteli et al.
Ernest Ivan
Gosteli Jacques
Lang Marc
Woodward Robert B.
Ciba-Geigy Corporation
Fishman Irving M.
Kolodny Joseph G.
Rizzo Nicholas S.
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