6-substituted mitomycin analogs

Details 6-substituted mitomycin analogs 6-substituted mitomycin analogs

1984-09-04

1989-12-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548422, C07D48714, A61K 3140

Patent

active

048883417

ABSTRACT:
Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is hydrogen or lower alkyl; and Z is a radical of the formula --O--R, wherein R is:

REFERENCES:
patent: 4746746 (1988-05-01), Remers
patent: 4803212 (1989-02-01), Vyas et al.
patent: 4814445 (1989-03-01), Vyas et al.
Kyowa, Chemical Abstracts, vol. 97, (1982), entry 55585c.
Urakawa, Chemical Abstracts, vol. 94, (1981), entry 30598j.

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